Diabetes School Forms
Shutting off inflammation (MIT)
Using short snippets of RNA to turn off a specific gene in certain immune
cells, scientists have shown that they can shut off the inflammation
responsible for diseases such as atherosclerosis.
This technique, known as RNA interference, offers a targeted way to stop
inflammation and could be useful in treating not only atherosclerosis, but
also other forms of heart disease as well as cancer, according to the
researchers.
Since RNA interference was discovered in 1998, its ability to potentially shut
off any gene in the body has intrigued scientists. RNA interference works by
disrupting the flow of genetic information from a cell’s nucleus to its
protein-building machinery. The key to success is finding a safe and effective
way to deliver short strands of RNA that can bind with and destroy messenger
RNA, which carries instructions from the nucleus.
In a study appearing in the Oct. 9 issue of _Nature Biotechnology_, the
researchers delivered short strands of RNA packaged in a layer of fat-like
molecules called lipidoids. These RNA-delivering nanoparticles successfully
reduced inflammation in mice, without side effects.
The research team includes MIT’s Daniel Anderson, associate professor in the
Harvard-MIT Division of Health Sciences and Technology, and Institute
Professor Robert …
Diabetes Patient Education Monitoring Blood Sugar
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